Dear Stephen,
My 21 year-old male relative has neuro lyme, bartonella and babesia. His past symptoms have been depression, anxiety and agitation, ADHD, explosive anger; more recently paranoia and brain fog and even more recently social withdrawal after a new July tickbite which caused a relapse apparently due to babesia. He tried the Buhner core protocol June of 2011 which caused extreme mood lability during the hour after each dose. His family had to leave the house for an hour each time as when the herbs killed the bacteria his impulse control went way down until the anti-inflammatory properties of the herbs kicked in and seemed to neutralize the inflammatory cascade. His family couldn’t sustain leaving the house for an hour three times a day for treatment so it was stopped. The herx’s from 4 different antibiotics he tried after that lowered impulse control so much they were discontinued, even when the antibiotic dosages were decreased. My relative’s current treatment is for babesia with the Byron White formula A-Bab. He has had a positive “energetic shift” which seems to indicate this is going well but extremely slowly so as to try and avoid herx reactions.


Current herx reactions happen anyway; every week to ten days. They are unpredictable and intense and mostly consist of extreme short-term rage which he struggles to control, at times very poorly. His current protocol is: A-Bab 2/3’s drop daily for babesia (maintenance dose 30 drops a day). He can tolerate this small dosage and it is being raised slowly. – Zinc picolinate/copper as per Buhner protocol to bind neurotoxins. These work very well for him – big difference in paranoia level. – Travacor for depression and anxiety (total daily zinc dose 60mg/last dose close to melatonin). This works somewhat. – 4 Lyprinol for inflammation (highly anti inflammatory marine oil) Unsure if this is helping. – 1800 EPA/1200 DHA Omegas daily. He does really well with Omegas-seem to help. – 1000 mg Niacin for high dopamine/social withdrawal. Okay but dose not high enough to solve the problem? Niacin somewhat antibiotic, when we raise to 2000mg it causes a herx. – 150mg Japanese knotweed 1x day. He can take this dose without an immediate herx. – 113mg Betasitosterol 3x day to bind toxins. Unsure if it helps. – 1275 mg Sarsaparilla 3x day Seems to tolerate this herb; unsure if this dosage is correct for him. – 60 drops Red Root tincture 3x day. This seems to help things flow; it reduced a lymph node in the neck that had been swollen for 10 yrs.


Even with a protocol which seems to have a number of things working well, there is still something central missing. Please give us your opinion if you can as to what changes you would make, as this young man’s family are at the end of their rope with the rages.


I have begun researching high histamine levels/low methylation issues and the relationship to systemic high ammonia levels. The type of sudden onset extreme rage seems consistent with a more minor angry outburst that I witnessed a year ago when my relative ate chicken and drank some lemonade. Within 15 minutes he had an outburst. I have read that the extreme alkalinity of lemonade can increase already high lyme ammonia levels and combined with the l arginine in the chicken can quickly create nitric oxide, causing brain swelling and psychiatric symptoms. My relative’s rages have that sudden intense type of quality to them. But even if this is correct – what to do? Thanks so much for your time. Right now this rage symptom seems to be the main obstacle in his lyme treatment. If we can solve it’ll make a huge difference for this young man and his family.


Stephen’s response:
in our experience explosive rage is usually bartonella generated (not always but usually). We highly recommend treating for bartonella. Reversing this can take time, in very extreme cases as much as a year to eighteen months. I would highly suggest he work with someone experienced in this area as the protocol usually needs extensive tweaking for each individual. My partner Julie McIntyre is highly experienced with it. Nevertheless, please see the bartonella protocol that is mentioned in depth on this site (it is more extensive than the book):
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